A chronicle of the things I find interesting or deeply important. Exploring generally 4 pillars of intense research. Dynamic Cognition (what every one else calls AI), Self Healing Infrastructures (how to build technological Utopia), Autonomous work routing and Action Oriented Workflow (sending work to the worker) and Supermortality (how to live...to arbitrarily long life spans by ending the disease of aging to death.)
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Life of a Cell video and other biology resources...
Harvard has a set of excellent online resources for detailed technical information concerning countless topics in science. Last year I came across the multimedia site for the biology department through a video called Inner Life this video shows in visual CGI glory the beautiful dance of biomolecules inside the cell. I have a very visual memory and the processes that I read about and could only imagine when I was in HS are put to beautiful motion in this video. Check out the different versions on the page with and without narration. The myocin molecule walking animation is an amazing demonstrating of a cyclic biomechanical operation that occurs simply because of a periodic affinity and bond energy change between the operative molecules...so beautiful. My favorite part was the mRna to protein synthesis segment of the animation, just like I always imagined it! The page also has animations of other cellular functions as well as demonstrations of conservation of energy principles. (which ultimately are the root source of ALL time evolved change weather it be in living or non living things)
Another resource I came across in 2005 is a general primer on DNA, mRNA transcription, and protein synthesis. Animations make the concepts described easy to comprehend.
This will surely go down as a seminal advance in cancer therapy. It reads like magic:
So this new approach looks for the specific proteins that are associated with a given tumors resistance to attack by the body's T cells, it then adjusts those T cells to be hyper sensitive to the specific oncogenic proteins targeted. These cells become essentially The Terminator T cells in the specific tumor AND have the multiplied effect of traveling along the immune pathway of spreading that the cancer many have metastasized. This is huge squared because it means you can essentially use targeting one tumor to identify and eliminate distal tumors that you many not even realize exist.
This allows the therapy for treating cancer to, for the first time; end the "wack a mole" problem that has frustrated traditional shot gun methods of treatment involving radiation and chemotherapy ...which by their nature unfortunately damage parts of the body that are not cancer laden but …
I have found as more non formally trained people enter the coding space, the quality of code that results varies in an interesting way.
The formalities of learning to code in a structured course at University involve often strong focus on "correctness" and efficiency in the form of big O representations for the algorithms created.
Much less focus tends to be placed on what I'll call practical programming, which is the type of code that engineers (note I didn't use "programmers" on purpose) must learn to write.
Programmers are what Universities create, students that can take a defined development environment and within in write an algorithm for computing some sequence or traversing a tree or encoding and decoding a string. Efficiency and invariant rules are guiding development missions. Execution time for creating the solution is often a week or more depending on the professor and their style of teaching code and giving out problems. This type of coding is devo…
Permissions, fine grained versus management headache
The usual method for determining which users can perform a given function on a given object in a managed system, employs providing those Users with specific access rights via the use of permissions. Often these permissions are also able to be granted to collections called Groups, to which Users are added. The combination of Permissions and Groups provides the ability to provide as atomic a dissemination of rights across the User space as possible. However, this granularity comes at the price of reduced efficiency for managing the created permissions and more importantly the Groups that collect Users designated to perform sets of actions. Essentially the Groups serve as access control lists in many systems, which for the variable and often changing environment of business applications means a need to constantly update the ACL’s (groups) in order to add or remove individuals based on their ability to perform certain actions. Also, the…