Why aging is caused mostly by degredation and is only modulated differentially by physiological factors
In an article recently posted about a talk given by Michael Rose, an analysis is performed of his theory that aging may not be caused by acquired systemic damage over time.
I give him dap for standing up for his view but I'll bethttp://www.blogger.com/img/blank.gif my hands (my most important body parts) he's wrong. Aging must be due mostly to a cumulative degenerative process. The simple answer comes from analyzing something I am sure Michael hasn't factored into his analysis and that is the relative difference in the number of translation and transcription events (ie places where mutations can happen) that exists between a fly and a human being. When you are as short lived as a fly, with a short cycle of cell recycling it becomes easy to have physiological effects dominate the longevity of an individual if well controlled (the results Michael got by controlling diet) but over the longer term the organism still is subject to mutations that slowly build up and lead t...